tag:www.tokiwaph.co.jp,2008-12-08:/en/research/news/13 2010-06-02T06:31:15Z Movable Type 4.1 tag:www.tokiwaph.co.jp,2010:/en/research/news//13.939 2010-05-31T05:35:24Z 2010-06-02T06:31:15Z

【2009】 Unique Coordination Mode of Potas...

tw001 【2009】
Unique Coordination Mode of Potassium Ions to Glycyrrhizin：X-ray Crystal Structure of Glycyrrhizin Dipotassium Salt
Yasuko In, Masaru Uchida, Masamichi Watanabe, Norio Aimi, and Toshimasa Ishida
Osaka University of Pharmaceutical Sciences, Tokiwa Phytochemical Co., Ltd, Chiba University
Chemistry Letters Vol.38, No.11

Economic importance of licorice
Hiroaki Hayashi, Hiroshi Sudo
Gifu Pharmaceutical University, Tokiwa Phytochemical Co., Ltd.
Plant Biotechnol, 26, 101-104. (2009)

Expressed sequence tags from rhizomes of Glycyrrhiza uralensis
Hiroshi Sudo, Hikaru Sek, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Atsushi Toyoda, Yasushi Totoki, Yoshiyuki Sakaki, Osamu Iida, Toshiro Shibata, Mareshige Kojoma, Toshiya Muranaka, Kazuki Saito.
Plant Biotechnol, 26, 105-107. (2009)


【2008】
Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin.
Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T.
Proc Natl Acad Sci U S A. , 105(37), 14204-14209. (2008)


【2007】
Oleanane-type Triterpene Glycisodes from Glycyrrhiza uralensis.
李楊金緯, Nakazima J, Kimura N, Saitou K, Senoo S
Tokiwa Phytochemical Co., Ltd., Chiba University
Nat Prod Comm, 2(3), 243-248. (2007)


【2002】
Identification of licocoumarone as an apoptosis-inducing component in licorice.
Watanabe M, Hayakawa S, Isemura M, Kumazawa S, Nakayama T, Mori C, Kawakami T.
University of Shizuoka, Tokiwa Phytochemical Co., Ltd., 三邦
Biol Pharm Bull., 25(10), 1388-1390. (2002)


【1995】
Extraction of DNA and RAPD Analysis from Dried Licorice Root.
Yamazaki M, Sato A, Shimomura K, Inoue K, Ebizuka Y, Murakoshi I, Saito K.
Chiba University, Tokiwa Phytochemical Co., Ltd.,
Nat Med, 49(4), 488-490. (1995)


【1994】
Genetic relationships among Glycyrrhiza plants determined by RAPD and RFLP analyses.
Yamazaki M, Sato A, Shimomura K, Saito K, Murakoshi I.　
Chiba University,Tokiwa Phytochemical Co., Ltd.,
Biol Pharm Bull, 17(11), 1529-1531. (1994)


]]> tag:www.tokiwaph.co.jp,2010:/en/research/news//13.940 2010-05-31T05:29:56Z 2010-06-02T06:29:07Z

【2006】 Bioavailability and tissue distri...

tw001 【2006】
Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats.
Ichiyanagi T, Shida Y, Rahman MM, Hatano Y, Konishi T.
Niigata University of Pharmacy
J Agric Food Chem., 54(18), 6578-6587. (2006)

Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism.
Rahman MM, Ichiyanagi T, Komiyama T, Hatano Y, Konishi T.
Niigata University of Pharmacy
Free Radic Res., 40(9), 993-1002. (2006)


【2004】
Structural dependence of HPLC separation pattern of anthocyanins from Bilberry (Vaccinium myrtillus L.).
Ichiyanagi T, Hatano Y, Matsuo S, Konishi T.
Niigata University of Pharmacy
Chem Pharm Bull (Tokyo)., 52(5), 628-630. (2004)

Simultaneous comparison of relative reactivities of twelve major anthocyanins in bilberry towards reactive nitrogen species.
Ichiyanagi T, Hatano Y, Matsuo S, Konishi T.
Niigata University of Pharmacy
Chem Pharm Bull (Tokyo)., 52(11), 1312-1315. (2004)

Kinetic comparisons of anthocyanin reactivities towards 2,2'-azobis(2-amidinopropane) (AAPH) radicals, hydrogen peroxide and tert-buthylhydroperoxide by capillary zone electrophoresis.
Ichiyanagi T, Hatano Y, Matsugo S, Konishi T.
Niigata University of Pharmacy
Chem Pharm Bull (Tokyo)., 52(4), 434-438. (2004)


【2003】
Comparisons of Anthocyanin Reactivity towards Hydroxyl Radical, Superoxide Anion and Singlet Oxygen.
Ichiyanagi T, Hatano Y, Matsugo S, Konishi T.
Niigata University of Pharmacy
New Tech. Med., 4(6), 788-792. (2003)


【2001】
Acid mediated hydrolysis of blueberry anthocyanins.
Ichiyanagi T, Oikawa K, Tateyama C, Konishi T.
Niigata University of Pharmacy
Chem Pharm Bull (Tokyo)., 49(1), 114-117. (2001)


【2000】
Comparison of anthocyanin distribution in different blueberry sources by capillary zone electrophoresis.
Ichiyanagi T, Tateyama C, Oikawa K, Konishi T.
Niigata University of Pharmacy
Biol Pharm Bull., 23(4), 492-497. (2000)

]]> tag:www.tokiwaph.co.jp,2010:/en/research/news//13.941 2010-05-31T04:00:51Z 2010-11-23T03:46:21Z

【2009】 Vasorelaxation Mechanisms of Quer...

tw001 【2009】
Vasorelaxation Mechanisms of Quercetin in Rat Arteries.
Seiichiro Nishida, Hiroyasu Satoh
Department of Pharmacology, Division of Traditional Herbal Medicine, Nara Medical University
Journal of US-China Medical Science, 6(10), 54-74, (2009)


【2007】
Suppression of oxidized LDL-induced PDGF receptor beta activation by ginkgo biloba extract reduces MMP-1 production in coronary smooth muscle cells.
Akiba S, Yamaguchi H, Kumazawa S, Oka M, Sato T.
Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan.
J Atheroscler Thromb., 14(5), 219-225. (2007)


【2006】
Cellular pharmacology and clinical effect of ginkgo biloba extract.
Sato H, Nishida S.
Department of Pharmacology, Nara Medical University
Food Function, 2(1), 17-21. (2006)

Cardiovascular Pharmacology of ginkgo biloba extract in rat: modulation on the sino-atrial node and vascular smooth muscles.
Sato H, Nishida S.
Department of Pharmacology, Nara Medical University
Food Function, 2(2), 107-112. (2006)

Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models.
Sakakibara H, Ishida K, Grundmann O, Nakajima J, Seo S, Butterweck V, Minami Y, Saito S, Kawai Y, Nakaya Y, Terao J.
University of Tokushima
Biol Pharm Bull., 29(8), 1767-1770. (2006)

Screening of Antidepressant-like Food Factors and Herbal Medicines.
Sakakibara H, Terao J
University of Tokushima
FFI Journal, 211(8), 720-726. (2006)

Modulating effect of ginkgo biloba extract on neurotransmitter level in brain.
Sakakibara H, Yoshino S, Matumura T, Ishizawa K, Kawazoe K, Tutiya K, Tamaki T, Kawai Y, Terao J.
University of Tokushima
Medical and Pharmaceutical Society for WAKAN-YAKU, 23th, Gifu, 2006

Ginkgo extraction thing
Sato K.
Tokyo medical and dental university, Tokiwa phytochemical CO., LTD
Safety guide book of functional food, 326-333. (2006)


【2005】
Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.
Nishida S, Satoh H.
Department of Pharmacology, Nara Medical University
Clin Chim Acta. 2005 Apr;354(1-2):141-6. Epub 2005 Jan 19.

Approach to novel functional foods for stress control 5. Antioxidsnt activity profiles of antidepressant herbs and their active components.
Mutsuko Shirai, Yoshichika Kawai, Rintaro Yamanishi and Junji Terao
Department of Food Science, Institute of Helth Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
The Journal of Medical Investigation Vol.52 Supplement 2005


【2004】
Comparative Electropharmacological Actions of Some Constituents from Ginkgo biloba Extract in Guinea-pig Ventricular Cardiomyocytes.
Satoh H.
Nara Medical University School of Medicine Dept. of Pharmacology
Evid Based Complement Alternat Med., 1(3), 277-284. (2004)

Aortic smooth muscles cellular pharmacology of ginkgo biloba extract.
Sato H, Nishida S.
Department of Pharmacology, Nara Medical University
Chinese medicine and the latest treatment13(3), 273-278. (2004)

Studies on interactions between functional foods or dietary supplements and medicines. III. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of nifedipine in rats.
Yoshioka M, Ohnishi N, Sone N, Egami S, Takara K, Yokoyama T, Kuroda K.
Kyoto Pharmaceutical University
Biol Pharm Bull., 27(12), 2042-2045. (2004)

Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers.
Yoshioka M, Ohnishi N, Koishi T, Obata Y, Nakagawa M, Matsumoto T, Tagagi K, Takara K, Ohkuni T, Yokoyama T, Kuroda K.
Kyoto Pharmaceutical University
Biol Pharm Bull., 27(12), 2006-2009. (2004)


【2003】
Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.
Nishida S, Satoh H.
Nara Medical University School of Medicine Dept. of Pharmacology
Life Sci, 72(23), 2659-2667. (2003)

Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes.
Satoh H.
Nara Medical University School of Medicine Dept. of Pharmacology
Arzneimittelforschung., 53(6), 407-413. (2003)

Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes.
Satoh H.
Nara Medical University School of Medicine Dept. of Pharmacology
Arzneimittelforschung., 53(6), 407-413. (2003)

Mechanism of vasorelaxant effect of quercetin.
Sato H, Nishida S.
Department of Pharmacology, Nara Medical University
Medical and Pharmaceutical Society for WAKAN-YAKU, 20th, Kumamoto, 2003

Influence of aging change on vasorelaxant effect of ginkgo biloba extract.
Sato H, Nishida S.
Department of Pharmacology, Nara Medical University
Medical and Pharmaceutical Society for WAKAN-YAKU, 20th, Kumamoto, 2003

Clinical effectiveness of ginkgo biloba extract to female cold constitution.
Morimasa T.
Brain Attack Center Ota Memorial Hospital
Medical and Pharmaceutical Society for WAKAN-YAKU, 20th, Kumamoto, 2003

Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats.
hnishi N, Kusuhara M, Yoshioka M, Kuroda K, Soga A, Nishikawa F, Koishi T, Nakagawa M, Hori S, Matsumoto T, Yamashita M, Ohta S, Takara K, Yokoyama T.
Kyoto pharmaceutical university
Biol Pharm Bull., 26(9), 1315-1320. (2003)

Current state and problem of herb and health food.
Seo S. Ishihara S.
Tokiwa phytochemical CO., LTD
Development and applied symposium of natural medicine, 2003


【2002】
The antianxiety effect of Ginkgo biloba Extract and the constituents assessed -elevated plus maze test in mice.
Kurihara H, Yoshihama T, Maruyama S.
Innovation Center for Cooperative Research of Gunma Univercity
Jpn Pharmacol Ther, 30, 955-962. (2002)

Mechanism of vasorelaxant effect induced by ginkgo biloba extract and constitutes.
Sato H, Nishida S.
Department of Pharmacology, Nara Medical University
Medical and Pharmaceutical Society for WAKAN-YAKU, 19th, Makuharimesse, 2002

Electropharmacological analysis on isolated ventricles muscle cell of ginkgo biloba extract and constitutes ginkgo biloba extract.
Sato H.
Department of Pharmacology, Nara Medical University
Medical and Pharmaceutical Society for WAKAN-YAKU, 19th, Makuharimesse, 2002


【2001】
New method of treatment to aftereffects of brain infarction -Clinical effectiveness of ginkgo biloba extract-
Morimasa T, Kibatake M, Oota K
Brain Attack Center Ota Memorial Hospital
Medicine and pharmacology, 46(6), 1013-1016. (2001)

Interaction of health food and the medicine(2): The ginkgo biloba extract inhibit CYP3A.
Kusuhara M, Oonishi N, Hori T, Matumoto K, Ymane K, Takayoshi K, Yoshioka M, Kuroda K, Yokoyama T.
Kyoto pharmaceutical university, Takarazuka city hospital
Pharmacokinetics, 16, S196 (2001)

【2000】
Protective effect of ginkgo extract on rat brain with transient middle cerebral artery occlusion.
Zhang WR, Hayashi T, Kitagawa H, Sasaki C, Sakai K, Warita H, Wang JM, Shiro Y, Uchida M, Abe K.
Department of Neurology, Okayama University Medical School, Japan.
Neurol Res, 22(5), 517-521. (2000)

Effect of effect of Ginkgo biloba leaf extract.
Ishizuka T.
Tokiwa phytochemical CO., LTD
New Food Industry, 43(9), 1-6. (2000)


【1998】
Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation.
Akiba S, Kawauchi T, Oka T, Hashizume T, Sato T.
Kyoto Pharmaceutical University
Biochem Mol Biol Int., 46(6), 1243-1248. (1998)


【1996】
Ginkgo biloba extract.
Nakamura H.
Tokiwa phytochemical CO., LTD
Materials of Functional Food, 303-308. (1996)


【1990】
Ginkgo biloba extract.
Nakamura H.
Tokiwa phytochemical CO., LTD
Materials of Functional Food, 363-366. (1990)


【1988】
HPLC analysis of ginkoglide with differential refractometer.
Komoda M, Nakamura H. Uchida M.
Tokyo medical and dental university , Tokiwa phytochemical CO., LTD
Tokyo medical and dental university, Medical device laboratory report


]]> tag:www.tokiwaph.co.jp,2010:/en/research/news//13.944 2010-05-31T04:00:41Z 2010-06-02T06:36:45Z

【2009】 Cardiotonic effect of Apocynum v...

tw001 【2009】
Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium
Irie K, Sato T, Tanaka I, Nakajima JI, Kawaguchi M, Himi T.
Musashino University, Tokyo Medical and Dental University, Tokiwa Phytochemical co., Ltd.
J Nat Med, 63, 111-116. (2009)

Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.
Grundmann O, Nakajima J, Kamata K, Seo S, Butterweck V.
University of Florida, Tokiwa Phytochemical co., Ltd.
Phytomedicine, 16, 295-302. (2009)


【2008】
Constituents from leaves of Apocynum venetum L.
Kazuaki Kamata, Shujiro Seo, Jun-ichiro Nakajima
J Nat Med, 62, 160-163. (2008)


【2004】
Apocynum venetum extract does not induce CYP3A and P-glycoprotein in rats.
Kobayashi M, Saitoh H, Seo S, Butterweck V, Nishibe S.　
University of Muenster, Health Sciences University of Hokkaido, Tokiwa Phytochemical co., Ltd. Kyoto Pharmaceutical University
Biol Pharm Bull., 27(10), 1649-1652. (2004)


【2002】
Antidepressant effects of Apocynum venetum leaves in the forced swimming test.
Seo S, Butterweck V., Sasaki T, Uchida M, Kobayashi M, Saitou K, Nishibe S
University of Muenster, Health Sciences University of Hokkaido, Tokiwa Phytochemical Co., Ltd, Kyoto Pharmaceutical University
The Pharmaceutical Society of Japan (122, in Chiba, 2002)


【2001】
Antidepressant effects of apocynum venetum leaves in a forced swimming test.
Butterweck V, Nishibe S, Sasaki T, Uchida M.
University of Muenster, Health Sciences University of Hokkaido, Tokiwa Phytochemical Co., Ltd.
Biol Pharm Bull., 24(7), 848-851. (2001) ]]> tag:www.tokiwaph.co.jp,2010:/en/research/news//13.942 2010-05-31T03:30:52Z 2010-05-31T08:36:23Z

【1985】 Structures of New Terpenoid Const...

tw001 【1985】
Structures of New Terpenoid Constituents of Ganoderma lucidum (Fr.) KARST (Polyporaceae).
Kohda H, Nakamura H, Ishihara S, Uchida M, Kohda H, Yamasaki K
Tokyo Medical and Dental University, Tokiwa phytochemical co., Ltd, Hiroshima University
Chem Pharm Bull (Tokyo)., 33(11), 4829-4835. (1985)

The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes.
Kohda H, Tokumoto W, Sakamoto K, Fujii M, Hirai Y, Yamasaki K, Komoda Y, Nakamura H, Ishihara S, Uchida M.
Hiroshima University, Tokyo Medical and Dental University, Tokiwa Phytochemical co., Ltd.
Chem Pharm Bull (Tokyo)., 33(4), 1367-1374. (1985)


]]> tag:www.tokiwaph.co.jp,2010:/en/research/news//13.943 2010-05-31T03:00:58Z 2010-05-31T09:04:31Z

【1999】 A-type proanthocyanidins from pea...

tw001 【1999】
A-type proanthocyanidins from peanut skins
H. Lou, Y. Yamazaki, T. Sasaki, M. Utida, H. Tanaka, S. Oka
National Institute of Bioscience and Human-Tachnology, Tokiwa Phytochemacal Co., Ltd.
Phytochemistry, 51(2), 297-308. (1999)

]]> tag:www.tokiwaph.co.jp,2010:/en/research/news//13.945 2010-05-31T02:30:56Z 2010-06-02T06:29:51Z

【2004】 Effects of continuous ingestion o...

tw001 【2004】
Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam.
Nishikawa M, Ariyoshi N, Kotani A, Ishii I, Nakamura H, Nakasa H, Ida M, Nakamura H, Kimura N, Kimura M, Hasegawa A, Kusu F, Ohmori S, Nakazawa K, Kitada M.
Chiba University、Tokiwa Phytochemical Co., Ltd.
Drug Metab Pharmacokinet., 19(4), 280-289. (2004)

【2003】
Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.
Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R.
J Ethnopharmacol, 87(1), 115-117. (2003)


【2003】
（The seasonal changes of the aucubin and geniposidic acid concentrations in Eucommia ulmoides OLIVER leaf）
Koike M, Nakamura H, Takahashi S
Nihon University, Tokiwa Phytochemical Co., Ltd.
J.Trad.Med., 15, 225-227. (1998)


【1993】
Quantitative Analysis of Deacylgymnemic Acid by High-Performance Liquid Chromatography.
Suzuki M, Ishihara S, Uchida M, Komoda Y
Tokiwa Phytochemical Co., Ltd., Tokyo Medical and Dental University
Yakugakuzassi, 113(4), 316-320. (1993)

Molecular phylogeny based on RFLP and its relation with alkaloid patterns in Lupinus plants.
Yamazaki M, Sato A, Saito K, Murakoshi I.
Chiba University, Tokiwa Phytochemical Co., Ltd.
Biol Pharm Bull., 16(11), 1182-1184. (1993)


【1989】
HPLC quantitative analysis of plantaginin in Shazenso (Plantago asiatica L.) extracts and isolation of plantamajoside.
Komoda Y, Chujo H, Ishihara S, Uchida M.
Tokyo Medical and Dental University, Tokiwa Phytochemical Co., Ltd.
Medical equipment laboratory report of Tokyo Medical and Dental University, 23, 81-85. (1989)


【1985】
Synthesis and antihypertensive activity of 5-(2-hydroxyphenyl)-1-(3-mercaptopropionyl)-2-pyrrolidinecarboxylic acids.
Kato E, Yamamoto K, Kawashima Y, Watanabe T, Oya M, Iso T, Iwao J.
Santen Pharmaceutical Co., Ltd.
Chem Pharm Bull (Tokyo)., 33(11), 4836-4846. (1985) ]]>