Scientific Papers_2019

Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer’s Disease Model Mice

【2019】

Kaori Taniguchi (a, Fumiko Yamamoto (a,b, Takuya Arai (b, Jinwei Yang (c, Yusuke Sakai (c,
Masayuki Itoh (d,Naomi Mamada (b, Masayuki Sekiguchi (e, Daisuke Yamada (f, Akiyoshi Saitoh (f,
Fuyuki Kametani (g,Akira Tamaoka (b, Yumiko M. Araki (h, Keiji Wada (e, Hidehiro Mizusawa (i and Wataru Araki (a

a) Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
b) Department of Neurology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
c) Tokiwa Phytochemical Co., Ltd, Sakura, Chiba, Japan
d) Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
e) Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
f) Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
g) Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
h) Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Juntendo University, Tokyo, Japan
i) National Center Hospital, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

DOI 10.3233/JAD-190098

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids-Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

【2019】

Shunsuke Nakamori,a,b Jun Takahashi,a,b Sumiko Hyuga,b Jinwei Yang,c Hiroaki Takemoto,a,b
Takuro Maruyama,d Naohiro Oshima,e Nahoko Uchiyama,d Yoshiaki Amakura,f Masashi Hyuga,d
Takashi Hakamatsuka,d Yukihiro Goda,d Hiroshi Odaguchi,b Toshihiko Hanawa,b and Yoshinori Kobayashia,b

a)Department of Pharmacognosy, School of Pharmacy, Kitasato University;
5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
b)Oriental Medicine Research Center of Kitasato University;
5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
c)Tokiwa Phytochemical Co., Ltd.; 158 Kinoko, Sakura, Chiba 285-0801, Japan
d)National Institute of Health Sciences; 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan
e)Faculty of Pharmaceutical Sciences, Tokyo University of Science;
2641 Yamazaki, Noda, Chiba 278-8510, Japan
f)Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University;
4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Biol. Pharm. Bull. 42, 1538-1544 (2019)

Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from Kaempferia parviflora for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells

【2019】

Yoshiki Miyata,a Jin Tatsuzaki,b Jinwei Yang,b and Hiroshi Kosano,a

a)Faculty of Pharma-Sciences, Teikyo University; 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
b)Tokiwa Phytochemical Co., Ltd.; 158 Kinoko, Sakura, Chiba 285-0801, Japan.

Biol. Pharm. Bull. 42, 1658-1664 (2019)

Effect of Continuous Ingestion of Kaempferia parviflora Extract (SIRTMAX®)-containing Diet on Glycemic Control and Safety Evaluation of Excessive Intake

【2019】

Tomoko Kuniyoshi,1 Yukiko Kobayashi,1 Norimoto Shimada,1 Jinwei Yang,1
Shin-ichiro Yamashita,2 Naoko Suzuki,2 and Tsuyoshi Takara3

1)Tokiwa Phytochemical Co., Ltd.
2)ORTHOMEDICO Inc.
3)Medical Corporation Seishinkai, Takara Clinic

Jpn Pharmacol Ther 2019; 47(11): 1841-50

Quality Evaluation and Characterization of Fractions with Biological Activity from Ephedra Herb Extract and Ephedrine Alkaloids-Free Ephedra Herb Extract

【2019】

Morio Yoshimura,a Yoshiaki Amakura,a Sumiko Hyuga,b Masashi Hyuga,c Shunsuke Nakamori,d Takuro Maruyama,c Naohiro Oshima,e Nahoko Uchiyama,c Jinwei Yang,f Hideki Oka,g Hideyuki Ito,h Yoshinori Kobayashi,d Hiroshi Odaguchi,b Takashi Hakamatsuka,c Toshihiko Hanawa,b and Yukihiro Godac

aCollege of Pharmaceutical Sciences, Matsuyama University
bOriental Medicine Research Center, Kitasato University
cNational Institute of Health Sciences
dDepartment of Pharmacognosy, School of Pharmacy, Kitasato University
eFaculty of Pharmaceutical Sciences, Tokyo University of Science
fTokiwa Phytochemical Co., Ltd.
gZeria Pharmaceutical Co., Ltd., Central Research Laboratories
hDepartment of Nutritional Science, Faculty of Health and Welfare Sciences, Okayama Prefectural University

Chem. Pharm. Bull. 68(2), 140-149 (2020)

Sleep improving effect of supplement containing Rafuma leaf extract.

【2019】

ラフマ葉エキス含有サプリメントの睡眠改善効果

Kinoshita K., et al.

Kitanotatsujin Corporation

Japanese Journal of Medicine and Pharmaceutical Science, 76(5), 755-758