Scientific Papers_Crude Drugs

Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer’s Disease Model Mice

【2019】

Kaori Taniguchi (a, Fumiko Yamamoto (a,b, Takuya Arai (b, Jinwei Yang (c, Yusuke Sakai (c,
Masayuki Itoh (d,Naomi Mamada (b, Masayuki Sekiguchi (e, Daisuke Yamada (f, Akiyoshi Saitoh (f,
Fuyuki Kametani (g,Akira Tamaoka (b, Yumiko M. Araki (h, Keiji Wada (e, Hidehiro Mizusawa (i and Wataru Araki (a

a) Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
b) Department of Neurology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
c) Tokiwa Phytochemical Co., Ltd, Sakura, Chiba, Japan
d) Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
e) Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
f) Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
g) Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
h) Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Juntendo University, Tokyo, Japan
i) National Center Hospital, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

DOI 10.3233/JAD-190098

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids-Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

【2019】

Shunsuke Nakamori,a,b Jun Takahashi,a,b Sumiko Hyuga,b Jinwei Yang,c Hiroaki Takemoto,a,b
Takuro Maruyama,d Naohiro Oshima,e Nahoko Uchiyama,d Yoshiaki Amakura,f Masashi Hyuga,d
Takashi Hakamatsuka,d Yukihiro Goda,d Hiroshi Odaguchi,b Toshihiko Hanawa,b and Yoshinori Kobayashia,b

a)Department of Pharmacognosy, School of Pharmacy, Kitasato University;
5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
b)Oriental Medicine Research Center of Kitasato University;
5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
c)Tokiwa Phytochemical Co., Ltd.; 158 Kinoko, Sakura, Chiba 285-0801, Japan
d)National Institute of Health Sciences; 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan
e)Faculty of Pharmaceutical Sciences, Tokyo University of Science;
2641 Yamazaki, Noda, Chiba 278-8510, Japan
f)Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University;
4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Biol. Pharm. Bull. 42, 1538-1544 (2019)

A Double-Blind, Randomized, Crossover Comparative Study for Evaluating the Clinical Safety of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE)

【2018】

HiroshiOdaguchi ,1 MarikoSekine ,1 SumikoHyuga ,1 ToshihikoHanawa,1 KeikaHoshi ,2 YoshinobuSasaki,3 MasakoAso,3 JinweiYang,4 MasashiHyuga,5 YoshinoriKobayashi,6 TakashiHakamatsuka,5 YukihiroGoda,5 andYujiKumagai3

1 OrientalMedicineResearchCenter,KitasatoUniversity,5-9-1Shirokane,Minato-ku,Tokyo108-8642,Japan
2 DepartmentofHygiene,KitasatoUniversitySchoolofMedicine,1-15-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0374,Japan
3 KitasatoUniversityHospitalClinicalTrialCenter,1-51-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0375,Japan
4 TokiwaPhytochemicalCo.,Ltd.,158Kinoko,Sakura,Chiba285-0801,Japan
5 NationalInstituteofHealthSciences,3-25-26Tonomachi,Kawasaki-ku,Kawasaki,Kanagawa210-9501,Japan
6 DepartmentofPharmacognosy,KitasatoUniversitySchoolofPharmacy,5-9-1Shirokane,Minato-ku,Tokyo108-8641,Japan

Evidence-Based Complementary and Alternative Medicine (2018). https://doi.org/10.1155/2018/4625358

Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias

【2018】

Hiroaki Takemoto, Jun Takahashi, Sumiko Hyug,Hiroshi Odaguchi, Nahoko Uchiyama, Takuro Maruyama, Tadatoshi Yamashita, Masashi Hyuga, Naohiro Oshima, Yoshiaki Amakura, Takashi Hakamatsuka, Yukihiro Goda, Toshihiko Hanawa, and Yoshinori Kobayashia

Department of Pharmacognosy, School of Pharmacy, Kitasato University; 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
Oriental Medicine Research Center of Kitasato University; 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
National Institute of Health Sciences; 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Faculty of Pharmaceutical Sciences, Tokyo University of Science; 2641 Yamazaki, Noda, Chiba 278-8510, Japan
College of Pharmaceutical Sciences, Matsuyama University; 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Biol. Pharm. Bull. 41, 247-253 (2018)

Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation(2017)

【2017】

Naohiro Oshima, Takuro Maruyama, Tadatoshi Yamashita, Nahoko Uchiyama, Yoshiaki Amakura, Sumiko Hyuga, Masashi Hyuga, Shunsuke Nakamori, Hiroaki Takemoto, Yoshinori Kobayashi, Takashi Hakamatsuka, Hiroshi Odaguchi, Toshihiko Hanawa, Yukihiro Goda

Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1, Kitakanemaru, Ohtawara city, Tochigi 324-8501, Japan
Division of Drugs, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
Oriental Medicine Research Center, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
Department of Pharmacognosy, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku,Tokyo 108-8641, Japan
Present Address: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

Journal of Natural Medicines (2017), DOI 10.1007/s11418-017-1111-8

Ephedrine alkaloids-free Ephedra Herb extract: a safer alternative to ephedra with comparable analgesic, anticancer, and anti-influenza activities(2016)

【2016】

Sumiko Hyuga, Masashi Hyuga, Naohiro Oshima, Takuro Maruyama, Hiroyuki Kamakura, Tadatoshi Yamashita, Morio Yoshimura, Yoshiaki Amakura, Takashi Hakamatsuka, Hiroshi Odaguchi, Yukihiro Goda, Toshihiko Hanawa

Oriental Medicine Research Center, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1, Kitakanemaru, Ohtawara city, Tochigi 324-8501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Journal of Natural Medicines (2016), 70, 571-583

Efficiently prepared ephedrine alkaloids-free Ephedra Herb: a putative marker and antiproliferative effects(2016)

【2016】

Naohiro Oshima, Tadatoshi Yamashita, Sumiko Hyuga, Masashi Hyuga, Hiroyuki Kamakura, Morio Yoshimura, Takuro Maruyama, Takashi Hakamatsuka, Yoshiaki Amakura, Toshihiko Hanawa, Yukihiro Goda

National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1, Kitakanemaru, Ohtawara city, Tochigi 324-8501, Japan
TOKIWA Phytochemical Co., Ltd., 158 Kinoko, Sakura-shi, Chiba 285-0801, Japan
Department of Clinical Research, Oriental Medicine Research Center of Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

Journal of Natural Medicines (2016), 70, 554-562