Scientific Papers_Rafuma

Effect of Apocynum venetum Leaf Extract (VENETRON®) on Unidentified Complaints Relating Menstruation in Healthy Female Subjects－A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study－

【2023】

Tomoko Kuniyoshi1), Yukiko Kobayashi1), Jinwei Yang1), Naoko Suzuki2), Tsuyoshi Takara3)

TOKIWA PHYTOCHEMICAL CO., LTD.
ORTHOMEDICO Inc.
Medical Corporation Seishinkai, Takara Clinic.

Jpn Pharmacol Ther

51(11), 1685-96 (2023)

“Health Management Supplement® Rafuma & GABA” for Employees Subscription-based supplements as an employee benefit to support your valued employees’ mental and physical health.

【2023】

Ayumi Horie, Yukiko Kobayashi

Tokiwa Phytochemical Co., Ltd.

FOOD STYLE 21
27(9) 82-85 (2023)

The effect of food containing Apocynum venetum leaf extract on daytime sleepiness, stress, in daily life, and concentration —A randomized, double—blind, placebo—controlled, crossover study—

【2022】

Kohei Fujiki1), Yuki Hirashima1), Takatoshi Ogami1), Akira Takano1), Tomoyasu Kamiya1), Kinya Takagaki1), Yoshitaka Iwama2)

1) Toyo Shinyaku Co., Ltd.
2) Nihonbashi Cardiology Clinic

Jpn Pharmacol Ther　
50 (4) 733-741 (2022)

Sleep improving effect of supplement containing Rafuma leaf extract.

【2019】

ラフマ葉エキス含有サプリメントの睡眠改善効果

Kinoshita K., et al.

Kitanotatsujin Corporation

Japanese Journal of Medicine and Pharmaceutical Science, 76(5), 755-758

Apocynum venetum Leaf Extract Exerts Antidepressant-Like Effects and Inhibits Hippocampal and Cortical Apoptosis of Rats Exposed to Chronic Unpredictable Mild Stress

【2018】

TingWu,1 XiangtingLi,1 TingtingLi,2 MinCai,1 ZhonghaiYu,1 JingsiZhang,1 ZhennianZhang,1 WenZhang,1 JunXiang,1 andDingfangCai 1

1 DepartmentofIntegrativeMedicine,ZhongshanHospital,FudanUniversity,Shanghai200032,China
2 ShanghaiUniversityofTraditionalChineseMedicine,Shanghai201203,China

Hindawi Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 5916451
https://doi.org/10.1155/2018/5916451

Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis

【2018】

Xiangting Li a, Ting Wu a, Zhonghai Yu a, Tingting Li b, Jingsi Zhang a, Zhennian Zhang a, Min Cai a, Wen Zhang a, Jun Xiang a, Dingfang Cai a,

a Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; Institute of Neurology, Academy of Integrative Medicine, Fudan University, Shanghai 200032, China
b Department of Neurology, Shuguang Hospital, Shanghai University Traditional Chinese Medicine, Shanghai 201203, China

https://doi.org/10.1016/j.biopha.2018.01.137

Effect of an Apocynum venetum leaf extract (VENETRON®) on sleep quality and psychological stress improvement: A randomized, double-blind, placebo-controlled, crossover study.

【2018】

Asami Nakata 1, Shin-ichiro Yamashita 2, Naoko Suzuki 2, Tingfu Liang 1, Tomoko Kuniyoshi 1, Jinwei Yang 1, Tsuyoshi Takara 3

1 Tokiwa Phytochemical Co., Ltd

2 ORTHOMEDICO Inc.

3 Medical Corporation Seishinkai, Takara Clinic

Japanese Pharmacology & Therapeutics, 46(1), 117-125 (2018)

Safety and Toxicological Evaluation of VENETRON® -A Botanical Health Product-

【2018】

（ベネトロン®の安全性及び毒性評価）

Tingfu Liang, Jinwei Yang, Tsutomu Ishikawa, Kuo-Hsiung Lee, Sansei Nishibe, Veronica Butterweck

Jpn Pharmacol Ther　2018　46（1）127-135
『薬理と治療』　2018年：46巻1号；127-135ページ

Endothelium-Dependent Relaxation Effect of Apocynum venetum Leaf Extract via Src/PI3K/Akt Signalling Pathway(2015)

【2015】

Yeh Siang Lau, Wei Chih Ling, Dharmani Murugan, Chiu Yin Kwan and Mohd Rais Mustafa

Department of Pharmacology, Faculty of Medicine, University of Malaya,
Graduate Institutes of Basic Medical Sciences and Vascular Biology Group, China Medical University and Hospitals

Nutrients, 7 (2015) 5239-5253.

The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract (2015)

【2015】

YAMATSU A, YAMASHITA Y, MARU I, YANG J, TATSUZAKI J and KIM M
Pharma Foods International Co., Ltd., Tokiwa Phytochemical Co., Ltd.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY Vol 61, No 2, (2015), 182-187

Cellular correlates of anti-depressant and anti-hypertensive effects of an aqueous extract of Apocynum venetum leaf, a medicinal herb from Xinjiang, China. (2011)

【2011】

Kwan CY, Leung YM1, Ku TC, Hsieh WT, Lau YS, Mustafa MR, Nishibe S, Tatsuzaki J
China Medical University and Hospitals, University of Malaya, University of Hokkaido and Tokiwa Phytochemical Co., Japan.
2011 International Conference on Food Factors

Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells. (2011)

【2011】

Kuo CS, Kwan CY, Gong CG, Tsai MF, Nishibe S, Tatsuzaki J
China Medical University, University of Malaya, University of Hokkaido and Tokiwa Phytochemical Co., Japan.
Journal of Ethnopharmacology 136, 149-155, (2011)

Safety Study of Apocynum venetum L. Extract in Healthy Adults.

【2009】

Jinwei Li-Yang 1, Ippei Tanaka 1, Veronika Butterweck 2, Syujiro Seo 1, Nobuhito Kimura 1, Tomohiko Uchida 3

1 Tokiwa Phytochemical Co., Ltd

2 College of Pharmacy, Department of Pharmaceutics, University of Florida, FL 32610, USA

3 Uchida Medical Clinic

Journal of Nutritional Food, 12(3), 1 -9 (2009)

The Stress Reducing Effect of γ-Aminobutyric Acid and Apocynum venetum Leaf Extract on Changes in Concentration of Salivary Chromogranin A.

【2009】

Ai YOTO 1, Shigemasa ISHIHARA 2, Jinwei LI-YANG 2, Veronica BUTTERWECK 3, Hidehiko YOKOGOSHI 1

1 School of Food and Nutritional Sciences, The University of Shizuoka

2 Tokiwa Phytochemical Co., Ltd

3 College of Pharmacy, Department of Pharmaceutics, University of Florida

Japanese Journal of Physiological Anthropology, 14(3), 55 (2009)

Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium (2009)

【2009】

Irie K 1, Sato T 2, Tanaka I 3, Nakajima JI 3, Kawaguchi M 1, Himi T 1.

1 Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University

2 Department of Natural Resources and Physiological Chemistry, Graduate School, Tokyo Medical and Dental University

3 Tokiwa Phytochemical Co., Ltd

J Nat Med, 63, 111-116 (2009)

Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.

【2009】

Grundmann O, Nakajima J, Kamata K, Seo S, Butterweck V.

University of Florida, TOKIWA Phytochemical Co., Ltd.
Phytomedicine, 16, 295-302. (2009)

Constituents from leaves of Apocynum venetum L. (2008)

【2008】

Kazuaki Kamata, Shujiro Seo, Jun-ichiro Nakajima
TOKIWA Phytochemical Co., Ltd.
J Nat Med, 62, 160-163. (2008)

Anti-anxiety Effects of Apocynum venetum L. in the Elevated Plus Maze Test.

【2007】

Oliver Grundmann 1, Jun-Ichiro Nakajima 2, Shujiro Seo 2, Veronika Butterweck 1

1 College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesvilla, FL 32610, USA.

2 Tokiwa Phytochemical Co., Ltd

Journal of Ethnopharmacology, 110(3), 406-411. (2007)

In vitro study on the antioxidant activity of VENETRON, an extract of Apocynum venetum L.

【2005】

Hirofumi Fujita 1, Yuuya Okimura 1, Toshihiko Utsumi 2, Yoshiki Takehara 3, Takuzo Fujiwara 1, Jitsuo Akiyama 4, Shujiro Seo 5, Kozo Utsumi 1

1 Institute of Medical Science, Kurashiki Medical Center

2 Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University

3 Department of Food and Nutrition, Faculty of Human Service, Okayama-Gakuin University

4 Doonan Institute of Medical Science, Akiyama Memorial Hospital

5 Tokiwa Phytochemical Co., Ltd.

Japanese Journal of Medicine and Pharmaceutical Science, 54(4), 491-503 (2005)

A Novel in vitro Endothelium-dependent Vascular Relaxant Effect of the Apocynum venetum Leaf Extract.

【2005】

Chiu‐Yin Kwan 1, Wen‐Bo Zhang 1, Sansei Nishibe 2, Shujiro Seo 3

1 Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

2 Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

3 Tokiwa Phytochemical Co. Ltd.

Clinical and Experimental Pharmacology and Physiology

Volume 32, Issue 9, 789-95. (2005)

1 Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster

2 Tokiwa Phytochemical Co. Ltd.

3 Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

Volume 75, Issue 3, 557-564. (2003)
Pharmacology Biochemistry and Behavior, 75, 557-564 (2003)

Antidepressant effects of apocynum venetum leaves in a forced swimming test. (2001)

【2001】

Butterweck V, Nishibe S, Sasaki T, Uchida M.
Westfälische Wilhelms-Universität, Health Sciences University of Hokkaido, TOKIWA Phytochemical Co., Ltd.
Biol Pharm Bull., 24(7), 848-851. (2001)