2019
Sleep improving effect of supplement containing Rafuma leaf extract.
【2019】 ラフマ葉エキス含有サプリメントの睡眠改善効果 Kinoshita K., et al. Kitanotatsujin Corporation Japanese Journal of Medicine and Pharmaceutical Science, 76(5), 755-758
Research & Development
2019
Patent
Sirtuin activator
JP6,417,630
2018
A Double-Blind, Randomized, Crossover Comparative Study for Evaluating the Clinical Safety of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE)
【2018】 HiroshiOdaguchi ,1 MarikoSekine ,1 SumikoHyuga ,1 ToshihikoHanawa,1 KeikaHoshi ,2 YoshinobuSasaki,3 MasakoAso,3 JinweiYang,4 MasashiHyuga,5 YoshinoriKobayashi,6 TakashiHakamatsuka,5 YukihiroGoda,5 andYujiKumagai3 1 OrientalMedicineResearchCenter,KitasatoUniversity,5-9-1Shirokane,Minato-ku,Tokyo108-8642,Japan2 DepartmentofHygiene,KitasatoUniversitySchoolofMedicine,1-15-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0374,Japan3 KitasatoUniversityHospitalClinicalTrialCenter,1-51-1Kitasato,Minami-ku,Sagamihara,Kanagawa252-0375,Japan4 TokiwaPhytochemicalCo.,Ltd.,158Kinoko,Sakura,Chiba285-0801,Japan5 NationalInstituteofHealthSciences,3-25-26Tonomachi,Kawasaki-ku,Kawasaki,Kanagawa210-9501,Japan6 DepartmentofPharmacognosy,KitasatoUniversitySchoolofPharmacy,5-9-1Shirokane,Minato-ku,Tokyo108-8641,Japan Evidence-Based Complementary and Alternative Medicine (2018). https://doi.org/10.1155/2018/4625358
2018
Apocynum venetum Leaf Extract Exerts Antidepressant-Like Effects and Inhibits Hippocampal and Cortical Apoptosis of Rats Exposed to Chronic Unpredictable Mild Stress
【2018】 TingWu,1 XiangtingLi,1 TingtingLi,2 MinCai,1 ZhonghaiYu,1 JingsiZhang,1 ZhennianZhang,1 WenZhang,1 JunXiang,1 andDingfangCai 1 1 DepartmentofIntegrativeMedicine,ZhongshanHospital,FudanUniversity,Shanghai200032,China2 ShanghaiUniversityofTraditionalChineseMedicine,Shanghai201203,China Hindawi Evidence-Based Complementary and Alternative MedicineVolume 2018, Article ID 5916451https://doi.org/10.1155/2018/5916451
2018
Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis
【2018】 Xiangting Li a, Ting Wu a, Zhonghai Yu a, Tingting Li b, Jingsi Zhang a, Zhennian Zhang a, Min Cai a, Wen Zhang a, Jun Xiang a, Dingfang Cai a, a Department of Integrative Medicine, Zhongshan Hospital, Fudan University,...
2018
A simple and effective preparation of quercetin pentamethyl ether from quercetin
【2018】 Jin Tatsuzaki1,2, Tomohiko Ohwada2, Yuko Otani2, Reiko Inagi3 and Tsutomu Ishikawa*1 1 Tokiwa Phytochemical Co. Ltd., 158 Kinoko, Sakura, Chiba 285-0801, Japan2 Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0013, Japan3 Graduate School...
2018
Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA
【2018】 Tatsuro Yamamoto1,2,6, Chiyomi Sakamoto1, Hiroaki Tachiwana2, Mitsuru Kumabe1, Toshiro Matsui 3, Tadatoshi Yamashita4, Masatoshi Shinagawa5, Koji Ochiai5, Noriko Saitoh1,2 & Mitsuyoshi Nakao1 1 Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku,...
2018
Effect of an Apocynum venetum leaf extract (VENETRON®) on sleep quality and psychological stress improvement: A randomized, double-blind, placebo-controlled, crossover study.
【2018】 Asami Nakata 1, Shin-ichiro Yamashita 2, Naoko Suzuki 2, Tingfu Liang 1, Tomoko Kuniyoshi 1, Jinwei Yang 1, Tsuyoshi Takara 3 1 Tokiwa Phytochemical Co., Ltd 2 ORTHOMEDICO Inc. 3 Medical Corporation Seishinkai, Takara Clinic Japanese Pharmacology & Therapeutics,...
Patent
Sirtuin activator
US9,745,279
2017
Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias
【2018】 Hiroaki Takemoto, Jun Takahashi, Sumiko Hyug,Hiroshi Odaguchi, Nahoko Uchiyama, Takuro Maruyama, Tadatoshi Yamashita, Masashi Hyuga, Naohiro Oshima, Yoshiaki Amakura, Takashi Hakamatsuka, Yukihiro Goda, Toshihiko Hanawa, and Yoshinori Kobayashia Department of Pharmacognosy, School of Pharmacy, Kitasato University; 5-9-1 Shirokane, Minato-ku,...