Scientific Papers

Mate

Here we show you researches conducted on mate.

Safety assessment of Ilex paraguariensis leaf extract（MATESOL®）on mutagenicity, acute toxicity and human excessive intake

【2026】

Yukiko Kobayashi 1, Haruka Oshikiri 1, Tomoko Kuniyoshi 1, Tsuyoshi Takara 2, Jinwei Yang 1

  1. TOKIWA PHYTOCHEMICAL CO., LTD.
  2. Medical Corporation Seishinkai, Takara Clinic.

Jpn Pharmacol Ther

2026, 54(7), 487-99

Reduction Effect of Ilex paraguariensis Leaf Extract (MATESOL®) on Abdominal Fat Area in Healthy Subjects ―A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study―

【2024】

 

Tomoko Kuniyoshi1, Haruka Oshikiri1, Yukiko Kobayashi1, Toyotada Ashino2, Ikuo Fukuhara3, Jinwei Yang1*

 

  1. Tokiwa Phytochemical Co., Ltd.
  2. New Drug Research Center, Inc.
  3. Fukuhara Clinic

 

Jpn Pharmacol Ther

52(9), 1067-1076(2024)

 

Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways

【2024】

 

Maya Kudo1*, Ming Gao1,2, Misa Hayashi1, Yukiko Kobayashi3, Jinwei Yang3 and Tonghua Liu4

 

  1. School of Pharmacy and Pharmaceutical Science, Mukogawa Women’s University
  2. Institute for Bioscience, Mukogawa Women’s University
  3. Tokiwa Phytochemical Co., Ltd.
  4. Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine

 

Food & Nutrition Research

68  (2024)