Research & Development

2024

Reduction Effect of Ilex paraguariensis Leaf Extract (MATESOL®) on Abdominal Fat Area in Healthy Subjects ―A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study―

【2024】 Tomoko Kuniyoshi1, Haruka Oshikiri1, Yukiko Kobayashi1, Toyotada Ashino2, Ikuo Fukuhara3, Jinwei Yang1* Tokiwa Phytochemical Co., Ltd. New Drug Research Center, Inc. Fukuhara Clinic Jpn Pharmacol Ther 52(9), 1067-1076(2024)

2024-10-01

Patent

Extraction fraction containing polymer condensation tannin obtained from ephedra extract or ephedrine alkaloids-free ephedra herb extract, and method of producing the same and use thereof

JP 7544322

2024-09-13

2024

Effects of Laurus nobilis Leaf Extract (LAURESH®) on Oral and Gut Microbiota Diversity in Mice

【2024】 Tetsuro Morikawa1, Durga Paudel2, Osamu Uehara3, Dedy Ariwansa1, Yukiko Kobayashi4, Jinwei Yang4, Koki Yoshida1 and Yoshihiro Abiko1 Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido,...

2024-07-01

Patent

Composition for improving unidentified complaints, depression, impaired concentration, decreased motivation for socialization and daily activities, autonomic nervous system disorders, pain, control and poor sleep quality associated with menstruation

JP 7498993

2024-06-12

2023

Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways

【2024】 Maya Kudo1*, Ming Gao1,2, Misa Hayashi1, Yukiko Kobayashi3, Jinwei Yang3 and Tonghua Liu4 School of Pharmacy and Pharmaceutical Science, Mukogawa Women’s University Institute for Bioscience, Mukogawa Women’s University Tokiwa Phytochemical Co., Ltd. Key Laboratory of Health Cultivation...

2024-01-23

Patent

COMPOSITION AND METHOD FOR IMPROVING QUANTITY OF TEAR FLUID, COMPOSITION, TREATING CONSTIPATION AND IMPROVING SKIN QUALITY

JP 7412743

2024-01-22

2023

Effect of Apocynum venetum Leaf Extract (VENETRON®) on Unidentified Complaints Relating Menstruation in Healthy Female Subjects－A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study－

【2023】 Tomoko Kuniyoshi1), Yukiko Kobayashi1), Jinwei Yang1), Naoko Suzuki2), Tsuyoshi Takara3) TOKIWA PHYTOCHEMICAL CO., LTD. ORTHOMEDICO Inc. Medical Corporation Seishinkai, Takara Clinic. Jpn Pharmacol Ther 51(11), 1685-96 (2023)

2023-11-16

Patent

Antibacterial agent against periodontal disease-associated bacterium and dental caries-associated bacterium, composition for periodontal disease prophylaxis and treatment, composition for cavity prophylaxis and treatment, composition for gum improvement, composition for gum ridge improvement, composition for inhibiting plaque accumulation, composition for xerostomia improvement, composition for saliva improvement, composition for inhibiting bad breath, and composition for constipation improvement

JP 7349742

2023-09-29

2023

“Health Management Supplement® Rafuma & GABA” for Employees Subscription-based supplements as an employee benefit to support your valued employees’ mental and physical health.

【2023】 Ayumi Horie, Yukiko Kobayashi Tokiwa Phytochemical Co., Ltd. FOOD STYLE 2127(9) 82-85 (2023)

2023-09-05

2023

Quantitative determination method of Aconitum monoester alkaloids using relative molar sensitivity (RMS) for the assay in the Japanese Pharmacopoeia

【2023】 Nahoko Uchiyama,a*) Junko Hosoe,a) Kyoko Ishizuki,a) Ryoko Arai,a) Naoki Sugimoto,a) Azusa Suzuki,b) Ryuji Asano,b) Yasushi Igarashi,b) Toru Miura,c) Yasuhiro Muto,c) Takako Suematsu,d) Takanori Komatsu,d) Taro Higano,e) Takun Furukawa,e) Norimoto Shimada,f) Yukihiro Goda a*) a) National Institute...

2023-08-18

Reduction Effect of Ilex paraguariensis Leaf Extract (MATESOL®) on Abdominal Fat Area in Healthy Subjects ―A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study―

Extraction fraction containing polymer condensation tannin obtained from ephedra extract or ephedrine alkaloids-free ephedra herb extract, and method of producing the same and use thereof

Effects of Laurus nobilis Leaf Extract (LAURESH®) on Oral and Gut Microbiota Diversity in Mice

Composition for improving unidentified complaints, depression, impaired concentration, decreased motivation for socialization and daily activities, autonomic nervous system disorders, pain, control and poor sleep quality associated with menstruation

Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways

COMPOSITION AND METHOD FOR IMPROVING QUANTITY OF TEAR FLUID, COMPOSITION, TREATING CONSTIPATION AND IMPROVING SKIN QUALITY

Effect of Apocynum venetum Leaf Extract (VENETRON®) on Unidentified Complaints Relating Menstruation in Healthy Female Subjects－A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study－

“Health Management Supplement® Rafuma & GABA” for Employees Subscription-based supplements as an employee benefit to support your valued employees’ mental and physical health.

Quantitative determination method of Aconitum monoester alkaloids using relative molar sensitivity (RMS) for the assay in the Japanese Pharmacopoeia

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