Scientific Papers

Safety assessment of SIRTMAX^®, a standardized Kaempferia parviflora rhizome extract: genotoxicity and oral toxicity studies

【2026】Haruka Oshikiri 1, Yukiko Kobayashi 1, Kwang-Soo Baek 2, Kunhee Park 2 and Jinwei Yang 1 TOKIWA PHYTOCHEMICAL CO., LTD.Daehan Chemtech Co., Ltd. Fundam. Toxicol. Sci.2026, 13(5), 185-196

• 2026-08-25

Safety assessment of Ilex paraguariensis leaf extract（MATESOL^®）on mutagenicity, acute toxicity and human excessive intake

【2026】Yukiko Kobayashi 1, Haruka Oshikiri 1, Tomoko Kuniyoshi 1, Tsuyoshi Takara 2, Jinwei Yang 1TOKIWA PHYTOCHEMICAL CO., LTD.Medical Corporation Seishinkai, Takara Clinic.Jpn Pharmacol Ther2026, 54(7), 487-99

• 2026-07-31

Safety evaluation on excessive intake of Laurus nobilis leaf extract（LAURESH^®） ―A randomized, double—blind, placebo—controlled, parallel—group comparison study―

【2026】Yukiko Kobayashi 1, Kanami Ishikura 1, Haruka Oshikiri 1, Tsuyoshi Takara 2, Tomoko Kuniyoshi 1, Jinwei Yang 1TOKIWA PHYTOCHEMICAL CO., LTD.Medical Corporation Seishinkai, Takara Clinic.Jpn Pharmacol Ther2026, 54(7), 477-86

• 2026-07-31

Mechanistic investigation of flavonoid-mediated inhibition of N-methyl-N-nitrosourea-induced mutagenicity via noncovalent DNA binding

【2026】 Chisato Matsuoka 1, Nao Takatama 1, Takuya Muraoka 1 and Keiko Inami 1   Division of Pharmaceutical Organic Chemistry, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University   Genes and Environment (2026) 48:13

• 2026-07-29

Kaempferia parviflora Rhizome Extract Improves Skeletal Muscle Glucose Homeostasis by Upregulating the GLUT4 Signaling Pathway In Vitro and In Vivo

【2026】 Seong-Hoo Park 1, Yeonhwa Lee 2, Soo-Jeung Park 3, Hyunyoung Choi 1, Jeongjin Park 2,4, Jinhak Kim 5,Kwang-Soo Baek 5, Kun Hee Park 5 and Woojin Jun 2,4   Research Institute of Medical Nutrition, Kyung Hee University Division of...

• 2026-07-29

NMR Characterization of Natural and Synthetic Anthocyanidins: Establishing a Foundation for Designing Functional O-Methylated Analogs

【2026】 Shunsei Shiozawa, Yukiko Kobayashi, Tadatoshi Yamashita, Jinwei Yang   Tokiwa Phytochemical Co., Ltd.   Natural product communications Volume 21, Issue 4, April 2026

• 2026-04-27

Natural food‐derived antimicrobials against beer spoilage microorganisms

【2025】Chang Liu 1, Jiale Tang 1, Peng Lu 1, Satoka Takabayashi 1, Dai Yagaki 1, Kenta Tsutsumi 1, Suguru Okuda 1,2, Hideaki Itoh 1, Hidenori Matsukura 3, Saki Toyota 3, Masaki Shimokawa 3, Koji Suzuki 4, Koji Nagata 1,2,5 1 Department...

• 2026-04-08

Evaluation of in vitro and in vivo genotoxicity, acute oral toxicity, and subacute oral toxicity of Apocynum venetum leaf extract VENETRON^®

【2025】 Yukiko Kobayashi, Haruka Oshikiri, Jinwei Yang   Tokiwa Phytochemical Co., Ltd.   Fundamental Toxicological Sciences Vol. 13, No. 1 , 5-17, 2026

• 2026-02-25

MATESOL®: A new anti-obesity ingredient made from yerba mate, the mysterious tea in South America

【2025】 Kanade Someno, Kanami Ishikura Tokiwa Phytochemical Co., Ltd. FOOD STYLE 2129(8) 56-58 (2025)

• 2025-08-04

A Randomized, Placebo-Controlled, Double-Blind Trial to Assess the Effects of Apocynum venetum L. (A. venetum) Venetron^® on Sleep and Stress in Those Expressing Feelings of Anxiety

【2025】   Kaitlyn P. White 1, Susan Hewlings 1,*, Corey Bryant 1, Megan Moseley 1, Christopher R. D’Adamo 2, Christopher S. Colwell 3, Jeff Chen 1 and Emily K. Pauli 1   Radicle Science, Inc. Department of Family and Community...

• 2025-06-20